Understanding Alzheimer's Risk Factors
Alzheimer’s disease can be defined as a degenerative brain disorder involving a progressive decline in memory and cognitive function. This challenging illness may disrupt not only the lives of those who live with it, but also those of their family members and caregivers. The often-isolating nature of Alzheimer’s frequently transforms familiar faces into strangers and simple tasks into significant challenges.
Recognizing Alzheimer’s risk factors to protect brain health
However, there may be notable value in understanding its genetic and environmental risk factors. Although there is no known cure for Alzheimer’s, recognizing the risk factors is often the first step in a comprehensive approach to maintaining brain health and mitigating the disease’s effects. By identifying and managing these factors, one can potentially delay the onset of the disease or slow its progression. Along with medical professionals, a licensed therapist can help individuals through this process in person or online.
Overview of Alzheimer’s disease
Alzheimer’s disease usually presents an array of symptoms that progressively impair cognitive function and personality. Early signs may include memory loss and confusion, often first observed as difficulty remembering recent events or information. As the disease progresses, tasks once considered routine may become difficult, contributing to frustration and changes in behavior or personality.
Stages of Alzheimer’s progression and dementia
The disease’s evolution can be classified into stages, starting from a pre-clinical phase where Alzheimer’s risk factors induce brain changes without noticeable symptoms. Mild or early-stage Alzheimer’s usually follows and can be characterized by more evident memory lapses. The moderate or middle stage typically marks a significant cognitive decline in which individuals usually require more assistance for day-to-day tasks. Last, severe or late-stage Alzheimer’s generally exhibits a substantial loss of cognitive and physical abilities.
Preventing Alzheimer's symptoms
Around 50 million people worldwide live with dementia (or memory loss) that is primarily caused by Alzheimer’s. This number is expected to double every few decades without advancements in treatment. As a result, the best way to manage Alzheimer’s may be to prevent it as best as possible. Understanding what may impact your chances of experiencing symptoms can be a crucial part of reducing the risk of dementia.
Genetic and hereditary risk factors
Experts usually agree that there can be a strong genetic component to Alzheimer’s. Certain genes passed down through generations can increase the risk of developing Alzheimer’s, which means a family history of the disease may amplify an individual’s susceptibility to it. The likelihood can further escalate if a parent or sibling has been diagnosed with the condition.
While genetics can significantly influence the risk of developing dementia, they are usually not the only factor that can do so. Other conditions, like heart disease and high blood pressure, can also boost a person’s risk level. Understanding genetic predisposition alongside other health conditions may become essential in identifying and managing the risk of dementia.
Non-genetic Alzheimer's risk factors
While genetics may significantly impact the risk of Alzheimer’s disease, non-genetic factors can also hold substantial sway. The first among these tends to be age, the greatest known risk factor. The majority (73%) of those with Alzheimer’s disease are usually at least 75 years old.
Cardiovascular health, blood pressure, and Alzheimer’s risk
Cardiovascular health can also contribute greatly to Alzheimer’s risk. Conditions like high blood pressure, heart disease, stroke, diabetes, and high cholesterol can impede blood flow, deprive brain cells of essential nutrients, and contribute to cognitive decline.
Impact of head injuries on Alzheimer’s disease
Another important non-genetic factor may be a history of head injuries, particularly traumatic brain injuries. Those incidents can cause lasting damage to the brain and increase the chances for an individual to develop Alzheimer’s disease.
Impact of lifestyle on Alzheimer’s risk factors
Finally, lifestyle choices may affect an individual’s Alzheimer’s risk. Habits like smoking, lack of exercise, poor diet, and heavy alcohol use can be classified as other risk factors that can lead to both cardiovascular disease and Alzheimer’s, emphasizing the importance of maintaining a healthy lifestyle for brain health.
Potentially modifiable risk factors for brain health
In the face of Alzheimer’s disease, certain environmental factors can be modified to reduce the risk of developing symptoms. Regular physical exercise can be a primary strategy because it generally promotes brain health by improving blood flow and cardiovascular health.
Diet and brain health
Diet is another adjustable factor that can significantly influence brain health. Adherence to a healthy diet abundant in fruits and vegetables, lean proteins, and whole grains is usually linked to a lower risk of dementia.
Sleep and mental stimulation in Alzheimer’s prevention
Good sleep hygiene can be a crucial but often overlooked aspect of preventing Alzheimer’s. Sleep disorders or poor sleep hygiene can exacerbate the risk, emphasizing the importance of adequate and quality sleep for brain health.
Additionally, mental stimulation through activities like reading, puzzles, and continuous learning may be instrumental in reducing the risk of Alzheimer’s.
The role of regular health checks and blood pressure
Doctors often serve as vital guides throughout this journey. They can provide advice on lifestyle changes that promote brain health, such as adopting a healthy diet, increasing physical activity, quitting smoking, and managing sleep disorders. In addition, they can recommend treatments to control other health conditions that might escalate Alzheimer’s risk.
Preventing and slowing the progression of Alzheimer’s
A multi-pronged approach may be best for preventing and slowing the progression of Alzheimer’s disease. Certain medications prescribed by healthcare professionals can help manage the symptoms and slow the disease’s progression. While they may not provide a cure, they can significantly improve the quality of life and extend periods of independence.
Non-medication approaches may also help individuals manage symptoms, whether with or without the additional support of medications. Examples can include cognitive stimulation therapy, mentally challenging activities, and music therapy, known for its calming effect and ability to stimulate memories.
Creating a supportive environment can likewise be key. This could mean maintaining routines to provide a sense of stability, using memory aids like calendars and notes, and ensuring a safe and comfortable living space.
When symptoms become severe or impact quality of life significantly, it may be necessary to see a therapist. They can provide coping strategies, address emotional needs, and guide clients and their families through the challenging journey of Alzheimer’s disease.
Benefits of online therapy for Alzheimer’s and dementia
Online therapy can be a beneficial tool for Alzheimer’s disease management. As the disease can often make traveling a challenge due to confusion and disorientation, the availability of online therapy may reduce potential stress. Additionally, online therapy can allow for flexible scheduling, accommodating the varying energy and concentration levels that can come with the disease.
Effectiveness of online therapy
One study analyzed and discussed how telemedicine could improve the quality of healthcare for Alzheimer’s disease and related dementias. It found that telehealth could provide high-quality, effective care for patients and their families despite its digital format. The study also noted that online interventions could increase opportunities for earlier intervention and lessen visits made to hospitals or emergency rooms.
Takeaway
What is the highest risk factor for dementia?
Research repeatedly shows that increasing age is the most important risk factor for dementia. According to the National Institute of Aging, less than 10% of Alzheimer’s cases develop before age 65. Past 65, the risk of developing Alzheimer’s disease doubles every five years.
What are three causes of Alzheimer's?
Although causes for Alzheimer’s may vary depending on the individual, scientists believe that, for most people, it is likely a combination of factors. Three of the most common causes include:
- Age-related brain changes
- Genetic variables
- Environment and lifestyle factors
Can lifestyle affect Alzheimer's disease?
While age increases risk, studies also link certain lifestyle habits to an increased risk of Alzheimer’s. These include:
Diet
A diet high in saturated and trans fats may increase the risk of Alzheimer's. A diet that includes vegetables, fruits, whole grains, and legumes instead of meats and dairy may help. For example, research shows the Mediterranean diet and the MIND diet—a hybrid of the Mediterranean and DASH (dietary approaches to stop hypertension diet) diet—may help reduce the risk of dementia.
Physical activity
Physical inactivity may increase the risk of Alzheimer's, while regular exercise may reduce an individual's risk. In studies on Alzheimer's and physical activity, researchers define "physical activity" as 20 to 30 minutes of exercise. While walking, running, and playing sports count as exercise, daily activities such as cooking, cleaning, or gardening can reduce the risk of Alzheimer’s, too.
Smoking
Alzheimer’s Research UK cites smoking as a strong risk factor for developing the disease. For example, one review found that cigarette smokers are up to 40% more likely to develop Alzheimer's disease than non-smokers. Another study from Finland showed heavy smokers in midlife were more than twice as likely to develop Alzheimer's and other forms of dementia two decades later. Smoking is considered a "modifiable risk factor," meaning that people who smoke more heavily have a higher risk for Alzheimer's, while those who quit can decrease their risk.
Sleep
Not getting enough sleep or not sleeping well may increase the risk of Alzheimer's. In a research setting, experts have found that people with sleep apnea may be at a higher Alzheimer’s risk because it can increase the buildup of proteins associated with Alzheimer’s called amyloid and tau. Sleep acts as a cleansing system that washes away tau and beta-amyloid plaques, potentially decreasing the risk of Alzheimer’s.
Social interaction
Being socially isolated may increase the risk of Alzheimer's by as much as 60% for some people. Research shows that individuals who live with or interact frequently with others on a monthly or weekly basis or are involved in community activities may have less risk of developing dementia.
Cognitive stimulation
Lack of mental stimulation may increase the risk of Alzheimer's, while regularly engaging in mentally stimulating activities can potentially prevent dementia or slow its progression. While researchers haven’t found strong evidence that “brain training” activities reduce the risk of dementia, such activities and cognitive stimulation therapy (CST) may help maintain and promote new brain connections and preserve thinking skills as one ages.
Chronic health issues
Unmanaged chronic health problems may increase the risk of Alzheimer's. These may include heart health issues, obesity, and conditions affecting the blood vessels, such as high blood pressure. Research has also drawn a link between hearing loss and dementia, showing that hearing aids can significantly reduce levels of brain atrophy, cognitive decline, and dementia risk for individuals experiencing hearing loss.
While they aren’t associated with lifestyle, certain medical conditions affecting brain functioning have also been linked to increased dementia risk. Examples include head injury or traumatic brain injury (TBI), inflammation, and certain types of brain infection. People with Down syndrome have a higher risk of developing early-onset dementia and Alzheimer's. There may be a relationship between epilepsy and Alzheimer’s disease, as well, as seizures can lead to neurodegenerative processes.
Is Alzheimer's hereditary?
Having a parent or sibling with Alzheimer's increases the risk of developing it; however, not everyone with genetic markers develops Alzheimer’s. For those who do have a familial history, the most associated is the APOE gene. There are three forms of the apolipoprotein (APOE) gene with different relationships to Alzheimer’s:
- APOE e2: The least common; this gene is associated with a reduction in the risk of Alzheimer’s.
- APOE e4: Slightly more common; this gene is associated with an increased risk of Alzheimer’s. Although it isn’t the case with everyone, inheriting one copy of the APOE e4 allele from a family member increases the chance of developing Alzheimer’s. Inheriting two copies can increase risk even more.
- APOE e3: Of the three genes, this is the most common. It’s a neutral risk factor.
Additionally, in less than 5% of cases, a genetic mutation passed down through families can cause early-onset familial Alzheimer’s disease (EOFAD). In such cases, people usually develop dementia symptoms before age 65 and sometimes as early as their 30s or 40s. Genetic testing isn’t typically done in most cases of Alzheimer's disease because increased risk is usually associated with a combination of this and other factors. Additionally, there isn’t a completely reliable test for the common form yet. However, a genetic counselor may recommend testing for families with a history of EOFAD.
What environmental factors cause Alzheimer's?
Scientists exploring the role that exosomes play in Alzheimer's etiology have found several possible environmental factors that may influence the disease’s development or reduction in some people. These might include:
- Exposure to air pollution
- Exposure to pesticides
- Exposure to heavy metals
- Socioeconomic status
- Education levels
- Living near a green space
How do you avoid getting Alzheimer's?
Experts say combining four or five healthy lifestyle changes might lower your risk of Alzheimer’s disease by 60%. These include engaging in regular physical activity, not smoking, adhering to a nutritious diet, maintaining a healthy weight, and participating in cognitive-boosting activities to cultivate a healthy brain.
Who is most affected by Alzheimer's?
Individuals over the age of 65 are the most affected by Alzheimer’s disease. Of this population, women are about twice as likely to develop Alzheimer’s (primarily because they tend to live longer than men).
At what age can Alzheimer's start?
While most people have late-onset Alzheimer's disease, where symptoms first appear in the mid-60s or later, some people have early-onset Alzheimer's. It's rare; however, these individuals may begin showing mild cognitive impairment leading to significant signs as early as their 30s, 40s, or 50s.
Is Alzheimer's curable?
Alzheimer's disease is a chronic condition for which there is no cure. However, there are treatments and support that can help people with the condition live as well as possible and, in some Alzheimer's cases (especially early onset dementia), reduce symptoms. For example, certain prescription medications can help treat early symptoms or those who develop symptoms in middle age. Resources and support are available through organizations like The Alzheimer’s Association and The National Institute on Aging to help people with Alzheimer’s and their families.
What are the 10 warning signs of Alzheimer's?
The warning signs tend to vary between individuals. Some people will show a few, while others will display many or all red flags. Here are the ten most common signs of Alzheimer's:
- Memory loss which disrupts daily life
- Problems with planning, problem-solving, and organization
- Trouble completing familiar tasks
- Confusion over place or time
- Trouble understanding visual and spatial relations
- Sudden trouble “finding” words when communicating.
- Frequently misplacing things and being unable to retrace one’s steps
- Withdrawal from social activities or work
- Unusually decreased or poor judgment
- Changes in personality or mood swings
- Previous Article
- Next Article