Can Anxiety Be Hereditary?

Medically reviewed by Laura Angers Maddox, NCC, LPC
Updated October 9, 2024by BetterHelp Editorial Team
Content warning: Please be advised, the below article might mention trauma-related topics that could be triggering to the reader. Please see our Get Help Now page for more immediate resources.

Understanding the causes of various mental health conditions can empower people to take preventative measures where possible. It can also help healthcare professionals offer more effective treatment options for those who do develop them. When it comes to anxiety disorders in particular, many wonder whether a genetic component may play a role in the development of this type of disorder. Read on to learn more about what researchers have uncovered so far about the causes of anxiety.

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What are anxiety disorders?

Many people experience a sense of worry from time to time related to certain situations, such as a job interview or a relationship conflict. It’s when this feeling of worry is so persistent that it impacts a person’s daily life and functioning that it may be classified as a clinical anxiety disorder. General symptoms of anxiety can include:

  • Persistent worry
  • A sense of impending doom or danger
  • Feeling restless or on edge
  • Difficulty concentrating
  • Difficulty sleeping
  • Irritability
  • Fatigue

There are many types of anxiety disorder. A person can have generalized anxiety disorder or another specific disorder within this category, such as panic disorder, social anxiety disorder, specific phobias, or separation anxiety disorder. Each of these qualifies as a separate diagnosis with distinct symptoms. According to the Anxiety and Depression Association of America, approximately 40 million people in the US experience an anxiety disorder each year. Below are three common anxiety disorders—generalized anxiety disorder, panic disorder, and social anxiety disorder. 

Generalized anxiety disorder

An individual may be living with generalized anxiety disorder (sometimes styled as generalised anxiety disorder) if they experience persistent, severe nervousness and worry in several different situations. Generalized anxiety disorder can have a significant impact on a person’s professional, social, and personal life. Typically, symptoms must have been present for six months for GAD to be diagnosed. 

Panic disorder

Panic attacks—sudden periods of intense anxiousness—are the primary feature of panic disorder. An individual living with panic disorder will typically develop a serious fear of experiencing another panic attack. People who suffer panic attacks may experience a racing heart, sweating, chills, and difficulty breathing, among other physical symptoms of anxiety. 

Social anxiety disorder

Marked by apprehension and worry during social situations, social anxiety disorder is usually related to an individual’s fear of being judged or otherwise perceived. For a diagnosis to be made, symptoms typically must have persisted for six months. 

The causes of anxiety

So, is anxiety genetic? And if so, how significant is the genetic factor when it comes to the causes of anxiety disorders? As with many other mental health conditions, anxiety disorders are thought to be caused by a confluence of factors. While there may be a relationship between anxiety-genetic components, there are various confounding factors to consider. Below, we’re discussing how a combination of certain environmental risk factors, a genetic predisposition, and other biological influences can cause an individual to develop an anxiety disorder.  

Genetic factors

Though anxiety is not considered a genetic disorder, genetic epidemiology studies suggest that individuals who have a family history of anxiety disorders are at increased risk of experiencing an anxiety disorder themselves. 

When it comes to generalized anxiety disorder (GAD), for example, research suggests that its incidence is at least partially hereditary. Family and twin studies show that GAD appears to have a genetic heritability of 31.6%

This means that approximately 31.6% of the differences in the risk of anxiety disorders can be ascribed to genetic and epigenetic mechanisms. Most researchers agree that there’s no single “anxiety gene” that’s solely responsible for anxiety disorders, but rather that a combination of genetic factors. If you’re dealing with anxiety symptoms, it may be worthwhile to ask family members if they’ve experienced an anxiety disorder in the past.

Research

Candidate gene studies show that there is substantial genetic correlation between anxiety disorders. Panic disorder and agoraphobia, for example, are frequently comorbid. In a large twin study on several anxiety disorders—published in the journal Depression and Anxiety (Depress Anxiety)—researchers concluded that panic disorder and agoraphobia likely have common genetic sources.   

According to genetic epidemiology studies, variations in gene expression impacting 5-HTT, MAOA, and several other genes have been connected to anxiety-related phenotypes. There is a significant association between 5-HTT, a serotonin transporter gene, and several psychiatric disorders, including major depressive disorder and anxiety disorders. Serotonin is a neurotransmitter that facilitates communication within the brain. According to Harvard Medical School, changes in the function of this and other brain functions are the primary mechanism by which genetics influence anxiety, impacting an individual’s control over the stress response. The link between the serotonin transporter gene and anxiety helps explain why selective serotonin reuptake inhibitors often work for anxiety disorders. 

Monoamine oxidase A (MAOA) is an enzyme that breaks down excess neurotransmitters. Studies have found a link between MAOA and self-reported anxiety. As with 5-HTT, MAOA impacts neurotransmitter function, which is important for controlling our mood. These are only two of the numerous candidate genes that could cause anxiety, but they help explain how genetic effects can contribute to the development of a disorder. 

The results of one genome-wide association study included several similar genetic influences, but also suggested that much of the genetic architecture of anxiety disorders consists of common variations in genes. Additionally, the study’s researchers found that there is high genetic correlation between anxiety, depression, and insomnia. They also concluded that variations in the candidate genes were consistent regardless of anxiety severity. 

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Environmental factors

A person’s environment consists of their family members, friends, school or work, and any other foundational people or places that shape the events of their lives. These elements could be past or present. For example, the past trauma of losing a loved one, experiencing active combat or a natural disaster, or being exposed to some type of abuse may contribute to the development of an anxiety disorder in a particular individual. Growing up with a caregiver who frequently exhibited symptoms of anxiety may also contribute to a person developing some of these flawed ways of thinking.

If you or a loved one is experiencing abuse, contact the Domestic Violence Hotline at 1-800-799-SAFE (7233). Support is available 24/7.

While some environmental stressors only briefly affect a person’s mood and mental health, other experiences can have long-term effects. The effects depend on both the individual and the stressors. In the words of one study published by the National Library of Medicine, people are products of their experiences “to an appreciable degree”, specifically with respect to symptoms of anxiety and depression.

Biological factors

People with anxiety may also have neural differences that contribute to their development of such a disorder. In the human brain, the amygdala is the area responsible for controlling stress, fear, and possibly anxiety, based on current research, and it may be wired differently in people with this type of disorder. It may be that their amygdala receives irregular signals from certain neurotransmitters, which are the chemical messengers of the brain. That’s why some healthcare providers may prescribe medication that targets the release of some of these messengers—such as norepinephrine, serotonin, and GABA—to help reduce symptoms in people with anxiety.

According to Harvard Health Publishing, these neurological irregularities may have a heritable component, meaning that brain structures or wiring may be partially genetic. More research is needed to isolate any specific genes that may be responsible for structure and controlling the brain's neurotransmitters, which could improve our understanding of how anxiety can develop and evolve throughout a person’s lifetime.

Differential susceptibility

In analyzing the relationship between genes, environment, and anxiety, some psychologists apply the hypothesis of “differential susceptibility”. It suggests that some children are more susceptible to adverse developmental experiences that may increase their likelihood of developing anxiety, depression, or related mental health conditions later in life. People with other mental health conditions such as biploar disorder may be more susceptible to develop an anxiety disorder too. Adverse experiences may include harsh parenting, neglect, or any traumatic event or exposure that shifts a child’s approach toward life and relationships.

In the psychological literature, children who bounce back from these experiences without long-term distress are sometimes referred to as “dandelions”, meaning that they tend to thrive despite the toughness of their environments. In contrast, children who are more sensitive to their environments are referred to as “orchids”, as they may require more specific types of support in order to recover from adverse experiences. This framework provides another angle from which one might view the potential interdependency of genetics and environment when it comes to mental health conditions like anxiety.

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When to seek support

Nearly everyone feels some sense of anxiety at various points in their life, such as before a high-stakes event like an exam, medical appointment, or performance. For many people, these feelings will dissipate after the event is over. However, for those who experience feelings of anxiety that are intense, consistent, and prevent them from fully engaging in daily life and relationships, it may be time to seek support for these symptoms. Meeting with a trained mental health care provider is often a recommended first step. 

If you’re interested in meeting with a healthcare provider in person, you can search for a therapist in your area. If you’d prefer to connect with a provider from the comfort of home, you might consider online therapy. Many people who can’t regularly travel to in-person appointments or have trouble finding a provider near them find online therapy to be a more convenient and available option. Online therapy methods such as cognitive behavioral therapy may be worthwhile, with research suggesting it can be an effective treatment for mental health conditions like anxiety and depression. With a virtual therapy platform like BetterHelp, you can get matched with a licensed therapist who you can meet with via phone, video call, and/or in-app messaging to address the challenges you may be facing.

Takeaway

While researchers don’t believe that heredity is the only factor in whether an individual may develop an anxiety disorder, studies suggest that it likely plays a role. If you’re experiencing symptoms of an anxiety disorder, you might consider meeting with a licensed mental health professional in person or online.
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