The mechanisms of interaction between the two conditions are still being examined. Current research suggests that, in addition to dementia’s ability to increase the likelihood of depression or worsen existing symptoms, depression may also worsen dementia.
Furthermore, evidence indicates that the link between dementia and depression may go much deeper than previously thought. One recent study found that those who are diagnosed with major depression early in life are twice as likely to develop dementia later in life. The results of that study suggest a substantial and complex connection between the two conditions that may offer clues as to the underlying causes of both.
There are significant challenges associated with accurately identifying depression symptoms when a person has dementia. The cognitive impairment that results from dementia can often make it difficult for individuals to express their feelings and articulate what’s causing their mood. In addition, there is a significant overlap between dementia symptoms and those caused by a depressed mood.
Some symptoms common to both include:
Furthermore, depression in patients who have dementia caused by a condition like Alzheimer’s disease might not appear the same as depression in those without a diagnosis of dementia. For example, symptoms of depression are often less severe in patients with dementia than in those without. The symptoms may come and go and not last as long. In addition, those with dementia are less likely to talk about and attempt suicide.
Evaluations for depression in dementia patients typically include:
Supporting a person with dementia and depression is typically best as a team effort. Friends, family members, medical providers, and other caregivers can all offer positive contributions to someone experiencing these conditions. You may also want to consider reaching out to support groups or advocacy organizations for help maintaining your own mental health as you care for your loved one.
Treating depression is complex no matter who is being treated, but its complexity increases substantially for older adults and even more so for those with dementia. Because of this, it’s typically highly beneficial to ensure that your loved one’s depression is being managed by their medical team. Conventional treatment for depression in dementia patients is typically broken into two categories: pharmacological and non-pharmacological.
Pharmacological interventions may involve the use of antidepressant medications like selective serotonin reuptake inhibitors (SSRIs). While SSRIs and other antidepressants are common components of treatment for depression in most populations, evidence suggests that they aren’t as effective in older people with dementia. As treatment guidelines improve, antidepressants are becoming less frequently prescribed, but medical providers may still utilize these or other medications to treat primary or secondary symptoms of depression in individuals with dementia.
Non-pharmacological therapies are those that do not involve medication. For example, a promising type of behavioral therapy called problem adaptation therapy (PATH) utilizes behavioral techniques to help those with dementia and depression manage their symptoms. Therapists meet with the patient in their home weekly for 12 sessions to teach them how to solve problems contributing to sadness, often involving caregivers to help bolster the patient’s problem-solving abilities. They’ll also work with the individual to develop a plan to avoid negatively charged situations and identify stimuli that trigger positive emotions.
PATH therapists usually teach their patients compensatory strategies too, such as using calendars, checklists, and other tools to bypass cognitive limitations. The results of a recent PATH study are encouraging: At the end of the trial, participant depression scores had decreased by 43% on average and disability scores had decreased by 93%.
The results of the PATH study cited above and other research initiatives indicate that likely some of the best ways to support a loved one with dementia and depression are to help them find positivity and encourage them to use compensatory strategies regularly. Talk to your loved one’s medical team and ask questions to better understand their capabilities and the strategies that might help. If they recommend specific compensatory strategies, you can help your loved one set up those strategies and encourage them to continue using them.
It will also likely be helpful to set up a system of reminders to help your loved one remember to take their medication or complete other tasks essential to their health. You might also want to help the person engage with pleasant memories to boost their mood, such as by creating a photo album they can flip through.
Some other common strategies that caregivers often find helpful for supporting individuals with dementia and depression include:
One final and crucial way caregivers may support their loved ones is by taking good care of themselves. Those with dementia are typically more responsive to negative emotions, so it can be important to present a calm, positive demeanor when assisting them. However, caregivers are often faced with substantial emotional and mental challenges as they support their loved one with dementia, which can sometimes make it challenging to maintain a calm attitude of positivity and empathy.
Caregiver stress is extremely common in those caring for loved ones with dementia, and it may be further increased by helping them manage depression as well. Caregiver stress, if unmanaged, often leads to burnout. A burned-out caregiver typically struggles to engage with their loved one, may not have the energy to assist them, and may struggle to empathize with them.
Caregiver stress can be prevented or managed by ensuring adequate self-care, engaging with your support network, and seeking therapy with a mental health professional. Many people are now turning to online therapy as their chosen method for receiving mental healthcare, though you can typically choose in-person care instead if desired, depending on your preference. Online therapists generally use the same evidence-based methods as traditional therapists and carry the same credentials.
Online therapy has the advantage of allowing you to attend sessions remotely from anywhere you have an internet connection; you don’t need to travel to your therapist’s office to meet with them. Recent research suggests that, in most cases, online therapy is just as effective as in-person therapy. Online therapy can be an effective intervention for cognitive impairments like dementia, as well as mood disorders such as depression.
Risk factors of depression can vary, but mental health and medical professionals generally agree that environmental and genetic factors play a part. Social isolation, the misuse of alcohol and other drugs, a family history of mood disorders, and experiencing traumatic or negative events have all been considered risk factors for developing depression. Older adults may have a higher risk of developing depression, especially when diagnosed with diseases such as Alzheimer’s disease. Not everyone who has these experiences will go on to develop the disorder, but they can increase one’s chances, especially if they have more than one risk factor. Poor cardiovascular health has also been found to correlate with higher rates of depression.
Depression is associated with many symptoms and unpleasant side effects. Some of the most common symptoms in depressed people include the following:
If an adult with dementia, particularly in its early stage, is experiencing symptoms of depression, they may benefit from talking therapies (such as behavioral treatment) or alternative therapies, even if they are already seeing a doctor for their medical conditions. Depression can lead to more severe dementia symptoms, and although the conditions share some of the same symptoms, neither should be taken lightly. Professional help may help the individual better cope with symptoms, manage feelings, and improve their daily well-being.
The primary diagnostic criteria for depression, according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) by the American Psychiatric Association, include prolonged sadness, apathy, and irritability that last for at least two weeks for most of the day every day. Persistent depression can affect memory and cognitive function. Physical symptoms, such as fatigue or appetite changes, might also occur. People with depression may also lose interest in activities that provide pleasure, such as hobbies, social connections, and enjoyable experiences.
According to a systematic review and controlled clinical trial, the most effective treatment for people with dementia and depression is combined home-based treatment and exercise with caregiver support. Social support from loved ones, such as trusted friends and family members, can also improve the mental health of a person with dementia, according to the Alzheimer’s Association. For those who don’t have support, this organization also offers support groups for people with Alzheimer's disease and dementia as Alzheimer’s progresses.
Dementia medications can have unique side effects, and not everyone will experience the same warning signs or complications. Take your own health into your hands by proactively checking in with your doctor about your prescriptions and symptoms. If you are the caregiver or loved one of someone with dementia who accompanies them to their appointments, ask their doctor how the medications might impact them, including mood and behavior. If you notice new or worsening symptoms or moods in your loved one, let the doctor know. Your observations can be important, as your loved one might not have the words to express the feelings or symptoms they’re experiencing.
The BetterHelp platform is not intended to provide any information regarding which medication or medical treatment may be appropriate for you. The content provides generalized information that is not specific to one individual. Do not take any action without consulting a qualified medical professional.
Depression in dementia is frequently explored in biological psychiatry and brain research, and several treatment methods are frequently recommended. Therapies like cognitive-behavioral therapy (CBT) and reminiscence therapy may be helpful for the psychological symptoms. Some doctors may also recommend psychiatric medications, such as antidepressants, although the effectiveness may differ from treatments in younger people. For those who have urges to take their own life, suicide prevention treatments and protocols may also be put into place, while still ensuring one’s medical symptoms are taken seriously and treated.
You can support a person with a mental illness by being empathetic, gentle, and patient with them, validating their feelings consistently. Understand that their mental health symptoms are not purposeful attempts to act out. Many people with these conditions struggle with daily living and self-care, as diseases like Alzheimer's impact their cognitive abilities. Support and love from someone in their life may make a significant difference to their emotional state, preventing negative outcomes that can lead to worsening symptoms.
You can be supportive of a person with depression in the following ways:
There are many options for support when living with depression. Therapy (talking therapies) and medication are generally considered the first options for treatment and can be used in conjunction for extra support or on their own. For those who have treatment-resistant depression, more intensive treatment methods may be more effective, such as transcranial magnetic stimulation (TMS) or electroconvulsive therapy (ECT). Alternative therapies, such as lifestyle adjustments, memory-support exercises, digital health tools, and herbal remedies, can also provide supplemental support. Talk to your doctor or therapist to explore your options and identify the most effective treatment for your needs.
Frequently, medicine, such as antidepressant medications, is prescribed to depressed people with dementia. These medications can contribute to reducing behavioral challenges and improving mood. Additionally, engaging in healthy lifestyle habits, like regular exercise and social interaction, may support memory and emotional well-being. However, talk to your doctor to explore which options are best for your unique situation, especially when managing complex diseases like dementia.