Brain Treatment For Depression: Exploring This Type Of Depression Treatment

Medically reviewed by Melissa Guarnaccia, LCSW
Updated February 13th, 2025 by BetterHelp Editorial Team

Depression is a mental health disorder that can negatively impact relationships, energy levels, mental well-being, and other aspects of day-to-day life, but it’s considered a treatable condition. Many people respond well to traditional treatments for major depressive disorder, such as talk therapy and medication. However, in cases of severe or treatment-resistant depression, doctors may recommend alternative approaches. Here, we’ll explore options for brain treatment for depression symptoms.

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What is brain treatment for depression?

Brain treatment, or brain stimulation therapy, is when a qualified medical professional actively stimulates certain regions of a patient’s brain in order to reduce symptoms of depression. Neurosurgeons, neurologists, and other qualified medical professionals who are trained to perform this treatment may use magnetic or electrical pulses to stimulate certain areas of the brain. One brain area they typically target is the prefrontal cortex, which is responsible for mood regulation. Since the prefrontal cortex is typically underactive in people with depression, small pulses may help excite prefrontal neurons, which may enhance brain function.

Why brain treatments can be effective for addressing anhedonia and other depression symptoms

One of the core symptoms of depression is anhedonia. People with anhedonia may lose interest in hobbies, social activities, and interactions and may have difficulty experiencing pleasure in general. The experience of anhedonia may indicate dysregulation in the brain’s reward system. 

Medical professionals may turn to brain treatments to address anhedonia when other approaches have not been effective. For example, selective serotonin reuptake inhibitors (SSRIs), a common depression medication, can further blunt emotions in certain individuals, which may exacerbate depression symptoms. Brain treatments may be a preferred alternative in such cases. This type of situation points to the need for personalized treatment plans for each individual living with depression.

Types of brain treatment for depression

Some people with depression may not respond to psychotherapy and medication, which can be referred to as treatment-resistant depression. While a doctor may recommend brain treatment for depression in such cases, there are various types to consider. Below are some key options. 

Transcranial magnetic stimulation (TMS) 

Transcranial magnetic stimulation (TMS) involves a qualified healthcare professional using magnetic pulses to stimulate nerve cells in the brain. TMS is a noninvasive brain stimulation procedure where a magnetic coil is placed on the head to induce the stimulation. Using their knowledge and experience with their patient, a healthcare professional like a doctor or psychiatrist will usually target a particular area that is believed to be causing symptoms. For example, they may target the dorsolateral prefrontal cortex for people with anhedonia. For severe depression, a provider may recommend repetitive transcranial magnetic stimulation, where multiple pulses are used in rapid succession for a potentially longer-lasting effect.

Electroconvulsive therapy (ECT) 

Electroconvulsive therapy (ECT) involves using electrical currents to stimulate nerve cells in the brain. ECT is also non-invasive brain stimulation, but it is performed under general anesthesia as the currents trigger a seizure in the brain. ECT activates most of the brain. Electrical impulses from electrodes placed on the head may provide rapid relief of depression symptoms in some individuals.

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Deep brain stimulation (DBS) and vagus nerve stimulation (VNS) 

Other brain stimulation therapies that may be used for treatment-resistant depression include deep brain stimulation (DBS) and vagus nerve stimulation (VNS). Deep brain stimulation is an invasive surgical procedure where electrodes are implanted into specific regions of the brain. From then on, the electrodes are always active and continuously modulate brain activity. Research suggests that DBS may significantly improve symptoms of chronic and treatment-resistant depression.

Vagus nerve stimulation (VNS) is also an invasive surgical procedure. In this case, an electrode is implanted close to the vagus nerve on the neck. The vagus nerve is a central part of the nervous system, which impacts one’s capacity for mood control. That’s why vagus nerve stimulation may help improve symptoms of depression and regulate mood on an ongoing basis.

Where brain stimulation therapies like transcranial magnetic stimulation (TMS) come from

While brain stimulation therapies can be particularly effective for treating depression, that was not always their primary use. Vagus nerve stimulation was originally designed as a treatment for epilepsy, electroconvulsive therapy was intended for schizophrenia and bipolar disorder, and transcranial magnetic stimulation was designed to assess the motor cortex in the brain. Today, any of these may be used to treat various mental illnesses, from obsessive-compulsive disorder (OCD) to severe major depression. 

Potential benefits and side effects of brain treatment for depression

By targeting nerve cells in the brain, stimulation therapies like transcranial magnetic stimulation may help treat depression symptoms. Below are some related potential benefits of brain stimulation therapies:

  • Increased energy and motivation
  • Improved mood and emotional stability
  • Decreased chronic pain
  • Improved sociability, which can enhance relationships with loved ones
  • More clarity of thought, which may make day-to-day decisions easier
  • Increased ability to adapt to change

In addition to the potential benefits, it can be important to be aware of possible side effects. Depending on the specific treatment, these may include headaches, nausea, muscle aches, confusion, short-term memory loss, mood changes, speech problems, and balance problems. Invasive treatments like DBS and VNS also carry inherent risks associated with any surgery. 

Can brain treatment be performed virtually?

Brain treatments are in-person procedures that must be performed in the office of a specialized medical professional. However, there are a number of steps that need to be taken before and after the procedure, which may be performed online in some cases. For example, the initial consultation and diagnosis, post-procedure check-ins, image results analysis, and treatment plan and symptom management discussions are all aspects of brain treatment that may take place online.

Online mental health care to treat depression symptoms and side effects

While physical procedures like brain treatments must be performed in person, other types of treatment for depression can be done online in many cases. For example, a person who has begun to experience symptoms of depression can meet with a provider online for a diagnosis and talk therapy treatment. This type and format of treatment can be particularly convenient for those who have few therapists in their area or who can't regularly commute to and from in-person therapy appointments. With a platform like BetterHelp, you can get matched with a licensed therapist and then meet with them virtually from anywhere you have an internet connection. You can also switch therapists at any time for no additional cost, which can make it easier to find the right fit.

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Can online therapy effectively treat depression?

While the brain stimulation therapies we’ve discussed here must take place with a medical professional in person, talk therapy treatment for depression can often be conducted online. Research suggests that online talk therapy can be as effective as in-person talk therapy for treating depression and anxiety in many cases.

Takeaway

For severe or treatment-resistant depression, brain stimulation therapies can often be beneficial for symptom reduction and management. These treatments are based on the relationship between the reward pathway in the brain and depression symptoms. Depending on the individual, forms of brain stimulation such as transcranial magnetic stimulation, electroconvulsive therapy, and vagus nerve stimulation may be effective. From enhancing everyday mood to increasing energy levels, there are many potential benefits of brain stimulation therapy. If you’re interested in this type of treatment, consult with your doctor or psychiatrist for personalized treatment advice.

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