Overview

Substance withdrawal, often known as withdrawal syndrome, is a set of symptoms that can occur when an individual significantly reduces or completely stops the intake of a substance on which they have become dependent. Removing a substance from the body can lead the body's natural mechanisms to cause withdrawal symptoms as it adjusts to the changes. Substances that may cause withdrawal include alcohol, prescription medications, or illicit drugs—as well as some other substances. 

Understanding other (or unknown) substance withdrawal

Other (or unknown) substance withdrawal may be diagnosed when symptoms of withdrawal are caused by an unknown substance. It may also be diagnosed when it’s caused by substance dependence or a substance use disorder1 not listed in The Diagnostic and Statistical Manual of Mental Disorders (DSM). 

Symptoms of other (or unknown) substance withdrawal can range from mild to severe, and may involve insomnia, anxiety, seizures, or hallucinations.2 The duration and severity of these symptoms can vary based on factors such as the type of substance, the duration of use, or the individual's overall health. 

Severe cases of substance withdrawal can lead to serious health complications if individuals do not receive appropriate medical supervision. These complications range from mild to potentially fatal, underscoring the importance of professional oversight during the withdrawal process. For example, alcohol withdrawal as a result of severe alcohol use disorder (formerly called alcohol abuse) may lead to a condition called delirium tremens, characterized by severe confusion, hallucinations, or seizures.

Symptoms

Other (or unknown) substance withdrawal can cause various physical and psychological symptoms, and the severity can range from mild to life-threatening depending on the type of substance used and the unique disposition of the individual.

Other (or unknown) substance withdrawal signs

Some of the most common symptoms of substance withdrawal may include the following. 

Physical symptoms

Physical symptoms of substance withdrawal often include: 

  • Tremors
  • Restlessness
  • Headaches
  • Vomiting
  • Sweating
  • Insomnia
  • Seizures
  • Digestive issues

Psychological symptoms

Below are some of the potential psychological symptoms of substance withdrawal: 

  • Anxiety
  • Depression
  • Irritability
  • Agitation
  • Hallucinations
  • Confusion

Behavioral symptoms

Behavioral symptoms of substance withdrawal can include: 

  • Social isolation
  • Loss of interest in previously enjoyed activities 
  • Changes in eating patterns
  • Agitation
  • Difficulty focusing 

When other (or unknown) substance withdrawal starts

Other (or unknown) substance withdrawal symptoms can vary in their onset depending on the type of substance or the individual's usage pattern. Often, these symptoms develop within a few hours to several days after discontinuing the substance. However, each person’s experience with substance withdrawal can differ.

Causes

The cause of substance withdrawal arises primarily from the body's physical dependence on a particular substance and the substance intoxication it induces. When a person uses certain drugs or medications over a prolonged period, they develop drug dependence, and their body starts to adapt to the constant presence of the substance. In cases of addiction, the body has learned to function normally with the drug or substance in its system. 

Other (or unknown) substance withdrawal explained

When an individual suddenly stops using a substance that the body has adapted to, the body reacts to this absence. This adjustment period, when the body is adapting to a new chemical makeup, is often what causes the varied symptoms of substance withdrawal. Substance withdrawal is a common bodily response, and professional help is available to manage these symptoms and guide individuals toward withdrawal recovery. 

Other (or unknown) substance withdrawal risk factors

Certain risk factors can make an individual more susceptible to substance addiction. Genetics can play a significant role in determining vulnerability to drug addiction. In addition, environmental factors such as exposure to substances at a young age, peer influences, lack of parental supervision, or socioeconomic status may also influence the risk of developing an addiction. Psychological factors, including stress, anxiety, depression, or other mental health conditions, may also lead to an increased risk of a substance-related disorder and dependence addiction.

 

Treatments

Substance withdrawal can be a challenging process, but with professional help and support, recovery is often achievable. It can be helpful to consider seeking the guidance of healthcare professionals when going through the withdrawal process from any substance. 

Other (or unknown) substance withdrawal treatment

Often, a combination of therapy, medication, medical treatment, and self-care is used to treat substance use disorders or complications with substance use withdrawal. 

Therapy 

Cognitive-behavioral therapy (CBT) can play a vital role in the treatment of substance withdrawal symptoms. CBT is a type of psychotherapeutic treatment that helps individuals understand the thoughts and feelings that influence their behaviors. CBT allows individuals undergoing other (or unknown) substance withdrawal to develop coping and mindfulness strategies for the uncomfortable symptoms often associated with the withdrawal process. By identifying the negative and self-destructive thought patterns that often accompany substance withdrawal, CBT may help individuals challenge or change their views regarding substance use.

Another method that may help treat substance use challenges is group therapy. Group therapy is one of the most widely used treatment approaches for individuals living with substance use disorders. It allows clients the opportunity to connect with others who may be living with similar challenges related to substance withdrawal. Clients can receive social support, encouragement, or advice from group members and learn new skills from the leading therapist or provider.

Studies have found that acceptance and commitment therapy (ACT) can also be helpful for individuals living with substance use disorders or challenges. This modality focuses on accepting and confronting challenges instead of avoiding them. In one study, participants undergoing ACT experienced a significant reduction in substance use and, in some cases, complete remission and sobriety.

Medication 

While medications are often used in managing substance withdrawal symptoms, it's important to emphasize receiving care from a licensed facility and specialized doctor in detox and substance abuse. 

Withdrawal from substances can be both physically and psychologically taxing, often requiring medical intervention to ensure health and safety. A licensed facility provides a controlled environment where appropriate medical care can be provided, minimizing risks or complications of substance withdrawal. Additionally, a licensed doctor specializing in detox and/or substance abuse, such as an addiction medicine specialist or emergency department physician, often has the expertise to assess individual health conditions, prescribe the appropriate medications, and monitor progress throughout the substance withdrawal process. 

Always consult a medical doctor before starting, changing, or stopping a medication for any condition. The information in this article is not a replacement for medical advice or diagnosis.

The BetterHelp platform is not intended for any information regarding which drugs, medication, or medical treatment may be appropriate for you. The content is providing generalized information, not specific for one individual. You should not take any action without consulting with a qualified medical professional.

Other substance withdrawal treatment options

Detoxification is often the first step in the process of recovery from substance addiction and withdrawals. It involves the body gradually adjusting to the absence of the addictive substance and “detoxing” the body of a substance. This process may involve uncomfortable and, in some cases, severe withdrawal symptoms as the body adjusts to the absence of the substance. 

It is often crucial to undergo detoxification under professional medical supervision to safely manage symptoms. Medication-assisted treatment (MAT) is often employed during the detoxification process to make it more tolerable. Detoxification is not a cure for substance addiction but serves as the starting point of an ongoing journey toward recovery. 

After treatment, it is recommended to be aware of potential triggers to avoid a relapse. The American Psychiatric Association recommends working closely with mental health professionals to identify personal triggers and develop coping strategies.

Self-care

Self-care can be a fundamental aspect of navigating the process of substance withdrawal. During substance withdrawal, the body undergoes a significant transformation as it works to restore equilibrium, making it essential to prioritize your physical well-being. 

Adequate sleep, nutritious food, and regular activity or exercise may mitigate substance withdrawal symptoms, boost energy levels, and aid in your body’s ability to recover. Mental self-care can be equally important for withdrawal from a substance (other or unknown). Engaging in mindfulness practices, meditation, or hobbies may cultivate a balanced mindset, reducing stress and cultivating resilience.

Resources

Several resources can be used to mitigate the impacts of withdrawal or substance use challenges, such as the following. 

Other (or unknown) substance withdrawal resources

Educational resources

The Substance Abuse and Mental Health Services Administration (SAMHSA) offers a host of articles, webinars, and toolkits on detoxification and substance use disorders. Additionally, they offer a national hotline that provides 24/7, 365-day-a-year treatment referral and information service for individuals or families facing mental or substance use disorders.

NIH.gov also serves as a beacon of support for those experiencing the challenges of withdrawal or substance addiction. As a repository of scientifically based information, it provides extensive resources to help individuals understand the complexities of substance dependence and the various stages of withdrawal recovery. 

The National Institute on Drug Abuse (NIDA), a part of the NIH, is particularly devoted to this cause, offering resources on substance use disorders, withdrawal symptoms, and effective treatment strategies. NIH.gov may offer assurance to individuals seeking additional support by providing evidence-based guidance every step of the way.

Support groups

Support groups can have a vital role in the recovery journey of individuals living with addiction and experiencing withdrawal symptoms. One of the most well-known is Alcoholics Anonymous (AA), a global community of individuals committed to sobriety where members discuss experiences and provide mutual support. Similarly, Narcotics Anonymous (NA) offers a service for those experiencing addiction to narcotics or other drugs/substances. 

Substance withdrawal support groups are not a one-size-fits-all solution—Each person may find different groups helpful based on their unique experiences and needs. The above-listed online resources may also point out local support groups near you.

For help with substance use, contact SAMHSA’s National Helpline at 1-800-662-HELP (4357).

Research

According to recent research, the standard of care for treating substance withdrawal symptoms is to utilize a combination of therapy and medication. According to their study, however, researchers are exploring other pathways that may improve the efficacy of these withdrawal treatment strategies. These new medications may help individuals more effectively taper off a substance and better engage in the withdrawal recovery process. 

Additional other (or unknown) substance withdrawal research

In another study, researchers looked at the importance of a holistic approach to treatment for individuals seeking to overcome other (or unknown) substance withdrawal symptoms and cope with ending an addiction. In their comprehensive review, researchers found that it can be crucial for treatment providers to consider the interplay of mental and physical health when designing treatment strategies. This study also found that the use of mindfulness-based practices such as meditation and yoga may serve as effective additions to care for individuals overcoming the other (or unknown) substance withdrawal symptoms of psychotropic medications.

Statistics

Below are several statistics on other (or unknown) substance withdrawal:

Other (or unknown) substance withdrawal statistics

  • Withdrawal symptoms occur in around 40% of individuals who experience an alcohol addiction, with the number related to specific drugs varying. 
  • 68% of individuals who complete detox find success in overcoming their addiction. 
  • 10% of individuals in the US have a substance use disorder at some point in their lives.
  • 60% of people living with addiction seek treatment via therapy, medical support, or other methods. 

Associated terms

Updated on September 6, 2024.
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